. Author manuscript; available in PMC: 2016 Sep 22.

Published in final edited form as: Breast Cancer Res Treat. 2015 Nov 23;154(3):591–608. doi: 10.1007/s10549-015-3643-5

Table 3.

Multivariable regression analysis on the association between change in OS and change in PFS between the experimental and control group

Private variable	Coefficient	SEM	p value
Intercept	−1.49	1.1
Change in median PFS	0.79	0.24	0.001
Region (vs. European)
Global	2.54	1.07	0.021
North American	0.39	1.22	0.75
Cross over permitted	2.73	1.22	0.029
≥3rd-line versus 1st/2nd-line trials	−3.1	1.33	0.023
Model R²	0.44

Dependent variable: change in median OS between the experimental and control groups of the study

PFS progression-free survival, OS overall survival, Adjusted R² proportion of variability in the dependent variable that is accounted for by the model