Georgopoulos 2001.

Study characteristics
Methods	Study design: paired‐eye, randomized controlled trial Number randomly assigned: 46 eyes of 23 participants; the fellow eye of each participant was the control Exclusions after randomization: not reported Losses to follow‐up: not reported Number analyzed: not reported, but "in 6 patients UBM study was available for pre‐ and post‐treatment evaluation" Unit of analysis: eye (both eyes per participant) Handling of missing data: not reported Sample size and power calculation: none reported
Participants	Country: not reported Mean age: 28 years (range 20 to 45 years); not reported by group Gender: 17 (74%) men and 6 (26%) women; not reported by group Inclusion criteria: clinically diagnosed pigmentary glaucoma in both eyes Exclusion criteria: not reported Equivalence of baseline characteristics: yes
Interventions	Laser: iridotomy using a neodymium:yttrium–aluminum–garnet (Nd:YAG) laser Control: pilocarpine 2% drops 1 or 2 times daily Length of follow‐up: Planned: not reported Actual: ranged from 6 to 23 months
Outcomes	Outcomes (primary and secondary outcomes not differentiated): uncontrolled IOP, defined as the proportion of participants who needed additional treatment for control of IOP (IOP > 21 mmHg), change in iris configuration measured by UBM Intervals at which outcome assessed: not reported Information on cost of interventions or quality of life: none reported
Notes	Study period: not reported Trial registration: none reported Source of funding: not reported Disclosures of interest: not reported Subgroup analyses: Changes in iris configuration were assessed in 12 eyes of 6 participants only; trial authors did not report reasons for inclusion or exclusion in subgroup analysis
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of randomization not reported
Allocation concealment (selection bias)	Unclear risk	Method of allocation concealment not reported
Masking of outcome assessors (detection bias) Visual field	Unclear risk	Visual field not reported as an outcome
Masking of outcome assessors (detection bias) Intraocular pressure	Unclear risk	Masking of IOP assessors not reported
Incomplete outcome data (attrition bias) All outcomes	High risk	Number of participants analyzed not reported for IOP outcomes. "In 6 patients UBM study was available for pre‐ and post‐treatment evaluation"; it was not clear why only 6/23 participants were part of the UBM study
Selective reporting (reporting bias)	Unclear risk	All outcomes mentioned in the Methods section of the conference abstract were reported in the Results section
Other bias	Low risk	None identified