Uva 1996.

Study characteristics
Methods	Study design: paired‐eye, randomized controlled trial Number randomly assigned: 32 eyes of 16 participants; the fellow eye of each participant was the control Exclusions after randomization: none reported Losses to follow‐up: none reported Number analyzed: 32 eyes of 16 participants Unit of analysis: eye (both eyes per participant) Handling of missing data: none Sample size and power calculation: none reported
Participants	Country: not reported Mean age: not reported Gender: not reported Inclusion criteria: bilateral pigmentary glaucoma under medical therapy Exclusion criteria: not reported Equivalence of baseline characteristics: not reported
Interventions	Laser: iridotomy using a yttrium–aluminum–garnet (YAG) laser Control: no treatment Length of follow‐up: Planned: not reported Actual: mean 28 months (range 12 to 37 months)
Outcomes	Outcomes (primary and secondary outcomes not differentiated): change in IOP, progression of visual field damage, change in iris configuration measured by UBM, change in signs of pigmentary glaucoma (Krukenberg spindle, iris transillumination, trabecular meshwork pigmentation) Intervals at which outcome assessed: not reported Information on cost of interventions or quality of life: none reported
Notes	Study period: not reported Trial registration: none reported Source of funding: not reported Disclosures of interest: not reported Subgroup analyses: none reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Investigators used a randomization table
Allocation concealment (selection bias)	Unclear risk	Method of allocation concealment not reported
Masking of outcome assessors (detection bias) Visual field	Unclear risk	Masking of visual field examiners not reported
Masking of outcome assessors (detection bias) Intraocular pressure	Unclear risk	Masking of IOP assessors not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	Investigators reported no participants lost to follow‐up
Selective reporting (reporting bias)	Unclear risk	No protocol or clinical trial registration record was available for assessment of selective outcome reporting. All outcomes mentioned in the Methods section of the conference abstract were reported in the Results section
Other bias	Low risk	None identified

AGIS: Advanced Glaucoma Intervention Study
IOP: intraocular pressure
mmHg: millimeter of mercury
UBM: ultrasound bio‐microscopy