Table 4.

Frequency of Common Symptoms in CNS Tumor Patients at EOL

Study/Symptom	Seizures	Speech problems	Dysphagia	Agitation, delirium or confusion	Neurologic deficits (CN, paralysis, gait)	Headache pain	Other
Vallero et al.,55 2014 39 children, mixed CNS tumors	41%	__	__	__	69% had CN deficit, 41% confined to bed w/ paralysis or changes in cognition/ consciousness	__	83% were on steroids, 58% receiving palliative sedation for agitation, seizures, dysphagia, dyspnea
Goldman et al.,56 2006 185 children, 59 w/ CNS tumors	39%	76%	62%	__	__	64%	69% had increased oral secretions; 62% had hearing or vision problem
Pace et al.,57 2009 169 adults, majority GBM	30%	__	85%	15%	__	36%	85% had drowsiness
Faithfull et al.,58 2005, 39 adults w glioma	56%	64%	__10%	51%	77% had poor mobility, 62% hemiparesis	62%	__
Sizoo et al.,59 2010 55 adults, mixed CNS tumors	45%	__	71%	29%	51% had focal neurologic deficits ,	33%	33% with progressive cognitive decline, 87% had drowsiness or impaired consciousness
Gofton et al.,60 2012, 168 adults, mixed CNS tumors	57%	27%	__14%	27%	65% had gait impairment, 58% had motor deficit	26%	22% had vision loss, 62% had cognitive/personality changes