Figure 1.

Function and structure in RHO mutation patients with class B phenotype. (A) P25, with a G106R mutation. Kinetic visual field has a superior hemifield scotoma that does not cross the horizontal meridian into the inferior field. Sensitivity profiles for light- and dark-adapted conditions are shown across the horizontal and vertical meridians (icons to right upper of each part of figure indicate location of data). Colocalized OCT cross-sectional images without and with highlighted laminae ONL (blue), EZ line (orange), and ROS (light blue). ONL thickness, EZ line visibility, and ROS thickness are plotted. Gray: normal limits for comparison with patient data. Hatched area is the location of the optic nerve head. (B) P24, with a T17M mutation. Kinetic field (V-4e) has a superior hemifield scotoma that does cross the horizontal meridian, and there is an extension of the scotoma around the central field, inferiorly (i.e., a pericentral defect). Sensitivity profiles across the horizontal and vertical meridians with colocalized and quantified OCTs (below). Mediation of dark-adapted sensitivities (based on sensitivity difference with two-color perimetry) is shown above data: R, rod; M, mixed rod and cone; C, cone; A, altitudinal; Pc, pericentral.