Table 2.

Pharmacodynamic Parameters of G-Pump Versus GlucaGen Glucagon.

Parameter dose	G-Pump		GlucaGen		G-Pump versus GlucaGen
	n	GeoMean (SD)a	n	GeoMean (SD)a	Estimate (SE)	90% CI	P value
Glucose Cmax (mg/dL)
0.3 μg/kg	19	177.6 (43.10)	16	162.0 (51.69)	1.18 (0.11)	1.01, 1.39	.0857
1.2 μg/kg	19	198.8 (49.37)	16	183.3 (66.15)	1.12 (0.12)	0.93, 1.35	.2944
2.0 μg/kg	19	212.6 (57.18)	16	200.6 (63.81)	1.11 (0.09)	0.96, 1.28	.2421
Glucose Tmax (minutes)
0.3 μg/kg	14	38.2 (29.62)	11	25.9 (28.38)	2.02 (0.95)	0.87, 4.66	.1619
1.2 μg/kg	18	49.5 (41.79)	16	31.2 (34.75)	1.31 (0.49)	0.68, 2.54	.4783
2.0 μg/kg	19	49.4 (40.59)	16	52.8 (20.21)	0.80 (0.16)	0.57, 1.13	.2825
Glucose T50%-early (minutes)
0.3 μg/kg	14	17.2 (8.76)	11	7.6 (9.45)	2.06 (1.19)	0.74, 5.75	.2349
1.2 μg/kg	18	21.9 (18.44)	16	14.5 (15.36)	1.25 (0.43)	0.69, 2.28	.5192
2.0 μg/kg	19	21.3 (16.52)	16	22.8 (6.51)	0.86 (0.19)	0.59, 1.25	.4864
Glucose AUC60 (mg/dL*minutes)
0.3 μg/kg	19	9587 (2820)	16	9032 (2983)	1.15 (0.12)	0.95, 1.39	.2178
1.2 μg/kg	19	10 421 (2637)	16	9791 (3584)	1.10 (0.11)	0.93, 1.31	.3245
2.0 μg/kg	19	10 609 (2763)	16	9943 (2692)	1.13 (0.09)	0.98, 1.29	.1399
Glucose AUC120 (mg/dL*minutes)
0.3 μg/kg	19	18 472 (6189)	16	17 374 (6300)	1.17 (0.14)	0.95, 1.43	.1970
1.2 μg/kg	19	21 406 (5563)	16	19 687 (7600)	1.13 (0.12)	0.94, 1.36	.2495
2.0 μg/kg	19	22 310 (6339)	16	21 057 (6653)	1.12 (0.09)	0.97, 1.30	.1930
Glucose AUC150 (mg/dL*minutes)
0.3 μg/kg	19	22 296 (7998)	16	21 005 (7931)	1.18 (0.14)	0.96, 1.46	.1883
1.2 μg/kg	19	26 251 (7110)	16	24 079 (9348)	1.15 (0.12)	0.95, 1.38	.2126
2.0 μg/kg	19	27 360 (8190)	16	25 845 (8624)	1.13 (0.10)	0.97, 1.31	.1890

^aDescriptive mean and standard deviation.