Table 2.

Results of generalized estimating equation models of the association between the biological response‐based proportion of days covered and glycated haemoglobin (HbA1c) level, stratified by HbA1c level before metformin initiation, adjusted for covariates

	Pre‐metformin HbA1c <8% (1770 patients)				Pre‐metformin HbA1c >8% (1330 patients)
	HbA1c values	Estimate	95% CI	p	HbA1c values	Estimate	95% CI	p
BRB‐PDC
0%	1089	Reference	—	—	585	Reference	—	—
1–49%	336	−0.107	−0.225, 0.011	0.077	240	0.043	−0.149, 0.236	0.659
50–79%	942	−0.113	−0.202, −0.025	0.012	683	−0.247	−0.390, −0.104	<0.001
≥80%	3529	−0.175	−0.257, −0.093	<0.001	2514	−0.453	−0.586, −0.320	<0.001

BRB‐PDC, biological response‐based proportion of days covered; CI, confidence interval; HbA1c, glycated haemoglobin.