Table 3.

Results of generalized estimating equation models of the association between glycated haemoglobin (HbA1c) and various levels of the biological‐response based proportion of days covered, stratified by HbA1c before metformin initiation, adjusted for covariates

	Pre‐metformin HbA1c <8% (1770 patients)				Pre‐metformin HbA1c >8% (1330 patients)
	HbA1c values	Estimate	95% CI	p	HbA1c values	Estimate	95% CI	p
BRB‐PDC
0–49%	1425	Reference	—	—	825	Reference	—	—
50–59%	271	0.009	−0.094, 0.112	0.859	221	−0.129	−0.297, 0.039	0.133
60–69%	300	−0.102	−0.190, −0.014	0.024	197	−0.278	−0.450, −0.106	0.002
70–79%	371	−0.124	−0.206, −0.042	0.003	265	−0.373	−0.518, −0.227	<0.001
80–89%	616	−0.127	−0.200, −0.053	<0.001	478	−0.534	−0.666, −0.403	<0.001
≥90%	2913	−0.151	−0.216, −0.087	<0.001	2036	−0.456	−0.572, −0.340	<0.001

BRB‐PDC, biological response‐based proportion of days covered; CI, confidence interval; HbA1c, glycated haemoglobin.