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. 2016 Sep 16;8:115–125. doi: 10.2147/CMAR.S83472

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© 2016 Biswas et al. This work is published and licensed by Dove Medical Press Limited

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Histopathology and immunohistochemistry of AT/RT.

Notes: Photomicrographs showing a heterogeneous tumor (A; HE, 100×) with areas of necrosis (B; HE, 100×) composed of small round cells admixed with cells with eosinophilic cytoplasm (C; HE, 200×); higher magnification shows typical rhabdoid cells (arrow) (D; HE, 400×). On IHC, tumor cells are positive for vimentin (E; IHC, 200×), EMA (F; IHC, 200×), synaptophysin (G; IHC, 200×), SMA (H; IHC, 200×), and focally for GFAP (I; IHC, 200×) and cytokeratin (J; IHC, 200×); MIB-1-LI is high (K; IHC, 200×) and tumor cells show loss of INI1, while endothelial cells (arrow) show retained expression (L; IHC, 200×).

Abbreviations: HE, hematoxylin and eosin; IHC, immunohistochemistry; EMA, epithelial membrane antigen; SMA, smooth muscle actin; GFAP, glial fibrillary acidic protein; MIB-1-LI, MIB-1 labeling index; INI1, integrase interactor 1; AT/RT, atypical teratoid/rhabdoid tumor.