Table 3.

Comparison of results of original model vs. models adjusted for minimally sufficient subsets (MSS) for effectiveness against PCV13-type and non-PCV13-type disease.^a

Modelb	VE (95% CI)		PCV13-type discordant pairsc	Absolute % difference in VE vs. unadjusted for PCV13-types
	PCV13	NVTa
Original (unadjusted, except for matching factors)	85.1 (73.8–91.9%)	21.4 (−18.8–47.7%)	96	Referent
Primary minimally sufficient confounding subset
MSS1¥: other children in household, influenza vaccination in the year before culture	83.5 (67.3–91.6%)	32.6 (−12.7–59.7%)	80	−1.6%
Additional minimally sufficient confounding subsets
MSS2¥: other children in household, crowding, influenza infection in 30 days before culture	81.2 (62.9–90.4%)	35.6 (−8.3–61.7%)	76	−3.9%
MSS3¥: caregiver education, crowding, influenza infection in 30 days before culture, prenatal care utilization, recent immigrant neighborhood	83.1 (55.1–93.6%)	39.2 (−6.5–65.3%)	52	−2.0%
MSS4¥: caregiver education, influenza vaccination in the year before culture, prenatal care utilization, recent immigrant neighborhood	82.4 (55.3–93.0%)	35.2 (−13.6–63.0%)	54	−2.7%

¥ All MSSs included adjustment for: matching factors (age and zip code), asthma, breastfeeding, underlying condition, daycare attendance, household income, insurance type at culture, race/ethnicity, and smoking exposure. Additional variables included in each subset indicated in table.

^aPCV13 = 13-valent pneumococcal conjugate vaccine; NVT = non-vaccine types; MSS = Minimally Sufficient confounding Subset.

^bAll models include adjustment for the matching variables, age and zip code. MSS1 was considered the primary subset due to less missing data (most discordant pairs retained).

^cBecause this is a conditional (matched) analysis, only matched sets which have discordant vaccination status (i.e., vaccinated case/unvaccinated control[s] or unvaccinated case/vaccinated control[s]) contribute to the analysis.