Table 1.
Results from study visits over 1 month for the lorcaserin (n = 17) and placebo (n = 19) groups
| Placebo (mean ± SE) |
Lorcaserin (mean ± SE) |
F† | P† | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Week 0 | Week 1 | Week 2 | Week 4 | Week 0 | Week 1 | Week 2 | Week 4 | |||
| Anthropometry | ||||||||||
| BMI (kg/m2) | 34.8 ± 1.2 | 34.8 ± 1.2 | 34.6 ± 1.2 | 34.7 ± 1.2 | 40.4 ± 1.3 | 40.2 ± 1.3 | 39.9 ± 1.3 | 39.6 ± 1.3 | 8.74 | 0.006* |
| WC iliac (cm) | 113.14 ± 2.99 | 114.68 ± 2.83 | 113.51 ± 2.55 | 115.7 ± 2.86 | 128.82 ± 3.085 | 128.18 ± 2.91 | 125.08 ± 2.63 | 127.01 ± 2.95 | 11.25 | 0.002* |
| WC umbilical (cm) | 111.92 ± 2.64 | 112.62 ± 2.56 | 113.68 ± 2.51 | 115.76 ± 2.42 | 126.54 ± 2.81 | 127.44 ± 2.72 | 125.32 ± 2.67 | 126.59 ± 2.57 | 13.52 | 0.001* |
| Hip (cm) | 118.32 ± 3.10 | 118.70 ± 2.99 | 117.094 ± 3.08 | 119.78 ± 2.88 | 130.40 ± 3.30 | 129.22 ± 3.18 | 129.15 ± 3.28 | 129.76 ± 3.07 | 6.7 | 0.015* |
| SBP (mmHg) | 130.47 ± 3.10 | 127.95 ± 2.75 | 133.90 ± 3.18 | 126.32 ± 2.73 | 124.18 ± 3.28 | 119.71 ± 2.91 | 123.94 ± 3.37 | 120.94 ± 2.88 | 6.22 | 0.018* |
| DBP (mmHg) | 77.37 ± 2.23 | 75.37 ± 2.26 | 75.53 ± 2.28 | 75.68 ± 2.28 | 74.88 ± 2.36 | 72.41 ± 2.39 | 77.06 ± 2.41 | 74.53 ± 2.41 | 0.28 | 0.600 |
| Energy expenditure | ||||||||||
| VO2 (L/min) | 0.26 ± 0.13 | ND | ND | 0.254 ± 0.011 | 0.262 ± 0.014 | ND | ND | 0.246 ± 0.012 | 0.03 | 0.859 |
| VO2/kg (mL/kg/min) | 2.49 ± 0.08 | ND | ND | 2.49 ± 0.09 | 2.29 ± 0.09 | ND | ND | 2.20 ± 0.10 | 4.15 | 0.05* |
| VCO2 (L/min) | 0.215 ± 0.011 | ND | ND | 0.211 ± 0.009 | 0.215 ± 0.012 | ND | ND | 0.198 ± 0.01 | 0.21 | 0.65 |
| Respiratory quotient | 0.829 ± 0.01 | ND | ND | 0.829 ± 0.011 | 0.818 ± 0.011 | ND | ND | 0.802 ± 0.012 | 2.38 | 0.132 |
| Resting energy expenditure (kcal/day) | 1,779.94 ± 85.14 | ND | ND | 1,748.21 ± 74.23 | 1,798.25 ± 92.87 | ND | ND | 1,683.50 ± 80.98 | 0.04 | 0.839 |
| Predicted basal metabolic rate (kcal/day) | 1,877.52 ± 68.91 | ND | ND | 1,871.31 ± 69.13 | 1,954.18 ± 75.09 | ND | ND | 1,952.81 ± 75.33 | 0.61 | 0.441 |
| Metabolic profile | ||||||||||
| Glucose (mg/dL) | 92.82 ± 2.14 | 94.35 ± 2.28 | 96.65 ± 2.74 | 94.06 ± 2.14 | 93.94 ± 2.14 | 92.29 ± 2.28 | 95.41 ± 2.74 | 90.53 ± 2.14 | 0.328 | 0.571 |
| Creatinine (mg/dL) | 0.88 ± 0.08 | 0.90 ± 0.06 | 0.94 ± 0.05 | 0.93 ± 0.06 | 0.88 ± 0.08 | 0.83 ± 0.06 | 0.85 ± 0.05 | 0.84 ± 0.06 | 0.614 | 0.439 |
| ALT (IU/L) | 24.77 ± 2.97 | 26.24 ± 3.76 | 24.12 ± 3.02 | 22.59 ± 3.14 | 17.35 ± 2.97 | 17.06 ± 3.76 | 18.12 ± 3.02 | 17.82 ± 3.14 | 2.413 | 0.13 |
| AST (IU/L) | 24.41 ± 2.04 | 27.65 ± 4.47 | 27.71 ± 4.25 | 21.71 ± 2.23 | 18.00 ± 2.04 | 16.94 ± 4.47 | 18.53 ± 4.25 | 17.18 ± 2.23 | 3.019 | 0.092 |
| GGT (IU/L) | 33.38 ± 5.22 | 39.25 ± 8.79 | 42.69 ± 11.26 | 36.19 ± 7.91 | 22.18 ± 5.07 | 20.82 ± 8.52 | 22.65 ± 11.12 | 19.65 ± 7.67 | 2.105 | 0.157 |
| Bilirubin (mg/dL) | 0.51 ± 0.08 | 0.46 ± 0.07 | 0.47 ± 0.08 | 0.44 ± 0.07 | 0.48 ± 0.07 | 0.46 ± 0.07 | 0.45 ± 0.07 | 0.47 ± 0.07 | 0.006 | 0.941 |
| INR | 1.16 ± 0.04 | 1.16 ± 0.03 | 1.08 ± 0.02 | 1.08 ± 0.07 | 1.06 ± 0.04 | 1.11 ± 0.03 | 1.08 ± 0.02 | 1.16 ± 0.07 | 0.188 | 0.667 |
| Prothrombin (time) | 12.13 ± 0.41 | 12.06 ± 0.33 | 11.26 ± 0.16 | 11.34 ± 0.77 | 11.01 ± 0.42 | 11.56 ± 0.34 | 11.34 ± 0.16 | 12.19 ± 0.79 | 0.168 | 0.684 |
| Apolipoprotein | ||||||||||
| A1 (mg/dL) | 153.94 ± 6.21 | 156.65 ± 6.99 | 155.18 ± 6.03 | 156.71 ± 6.51 | 139.24 ± 6.21 | 130.47 ± 6.99 | 131.65 ± 6.51 | 126.41 ± 6.51 | 7.806 | 0.009* |
| B (mg/dL) | 88.78 ± 4.51 | 87.22 ± 6.16 | 85.17 ± 6.06 | 90.94 ± 4.55 | 89.89 ± 4.64 | 88.00 ± 6.34 | 87.65 ± 6.24 | 84.88 ± 4.68 | 0.004 | 0.95 |
| Total cholesterol (mg/dL) | 175.76 ± 6.68 | 176.47 ± 7.32 | 176.00 ± 6.97 | 178.70 ± 6.91 | 175.31 ± 6.89 | 167.00 ± 7.54 | 170.06 ± 7.18 | 164.12 ± 7.13 | 0.67 | 0.419 |
| CANTAB test results | ||||||||||
| IED total errors | 20.10 ± 4.04 | 12.60 ± 2.24 | ND | 11.00 ± 1.36 | 14.75 ± 4.52 | 13.25 ± 2.50 | ND | 7.25 ± 1.52 | 1.004 | 0.331 |
| SSP span length | 5.53 ± 0.44 | 6.00 ± 0.34 | ND | 6.10 ± 0.39 | 5.41 ± 0.46 | 5.06 ± 0.36 | ND | 5.23 ± 0.41 | 1.63 | 0.21 |
| SST (last half) | ||||||||||
| SSD (50%) | 358.01 ± 41.46 | 370.38 ± 46.92 | ND | 313.66 ± 45.22 | 313.16 ± 43.83 | 314.84 ± 49.60 | ND | 258.11 ± 47.81 | 0.818 | 0.372 |
| SSRT | 169.94 ± 24.23 | 165.72 ± 25.52 | ND | 177.24 ± 27.60 | 225.55 ± 25.62 | 228.60 ± 26.98 | ND | 224.30 ± 29.18 | 2.762 | 0.106 |
| SWM between errors | 44.11 ± 5.02 | 41.06 ± 4.69 | ND | 46.17 ± 6.55 | 55.23 ± 5.17 | 51.88 ± 4.82 | ND | 50.71 ± 6.74 | 1.632 | 0.21 |
| SWM strategy | 27.56 ± 1.14 | 27.72 ± 1.42 | ND | 27.39 ± 1.20 | 30.29 ± 1.17 | 30.47 ± 1.46 | ND | 28.71 ± 1.23 | 2.131 | 0.154 |
| VRM total correct | 6.79 ± 0.56 | 8.10 ± 0.44 | ND | 8.32 ± 0.52 | 6.29 ± 0.59 | 6.76 ± 0.46 | ND | 7.18 ± 0.55 | 2.581 | 0.117 |
fMRI testing took place at weeks 0, 1, and 4. There was an intermediate visit at week 2 for patient check-in with the physician.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CANTAB, Cambridge Neuropsychological Test Automated Battery; DBP, diastolic blood pressure; GGT, γ-glutamyl transferase; IED, intra-/extra-dimensional set shift; INR, international normalized ratio; ND, no data (some assessments were done at select visits); SBP, systolic blood pressure; SSD, stop signal delay; SSP, spatial span; SSRT, stop signal reaction time; SST, stop signal task; SWM, spatial working memory; VRM, verbal memory; WC, waist circumference.
†The F and P values are from repeated-measures ANOVA over time between the two groups.
*P < 0.05, FWE corrected for peak.