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. 2016 Jul 13;65(10):2911–2919. doi: 10.2337/db16-0305

Figure 7.

Figure 7

VWR upregulates GLUT4 protein expression independent of Torin 1–sensitive mTORC1 signaling. Data for lean mice treated with Torin 1. A: Representative immunoblots for relative GLUT4, phospho-S6K, phospho-4E-BP1, and tubulin. B: Quantity of GLUT4 protein determined by densitometry. C: Effect of Torin 1 on insulin-mediated downstream mTORC1 pathway signaling. D and E: Right-side quadriceps muscle weight (D) and total accumulated running distance (E) for mice treated with Torin 1. n = 3 animals/group. Data are mean ± SEM. †P < 0.05, VWR effect. QUAD, quadriceps; SED, sedentary; TOR1, Torin 1 treated; VEH, vehicle treated.