Figure 3.

SERCA2 deficiency leads to decreased insulin secretion. A: Serum insulin levels were measured in S2HET (HET) and WT mice fed the HFD for 16 weeks at time 0 after a 5-h fast and 10 min after an intraperitoneal injection of glucose (2 mg/kg total body weight). B: Islets were isolated from HFD-fed S2HET and WT mice, and GSIS was measured and normalized to total insulin content. Results are displayed as the means ± SEM from three or more independent experiments for each group. Indicated comparisons are significantly different: *P < 0.05; ***P < 0.001; n.s. indicates that no significant differences were observed between groups.