Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 9;65(10):3111–3128. doi: 10.2337/db15-1563

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

PMC Copyright notice

Hsp20-mediated cardioprotective effects are largely offset by blockade of the exosome generation. A: A scheme of the experimental procedure for the treatment of mice with STZ and GW4869. B: Exosome concentration was measured in the serum of mice treated with GW4869 (n = 5). *P < 0.05 vs. WT; #P < 0.001 vs. DMSO-treated control groups. C: Representative echocardiographic images. LVIDd (D) and LVEF% (E) were calculated in various groups as indicated (n = 5 for buffer-treated groups and n = 7 for STZ-treated groups). *P < 0.05 vs. STZ/DMSO-treated WT. Hsp20-mediated attenuation of cardiomyocyte hypertrophy (F and G), cardiac apoptosis (H and I, arrows indicate TUNEL-positive nuclei), and Hsp20-mediated promotion of myocardial angiogenesis (J and K) were significantly limited by the GW4869 treatment (n = 5 hearts, with two sections from each heart). Scale bars: 100 μm. *P < 0.05 vs. STZ/DMSO-treated WT. Ctl, control; Mon, month.

Hsp20-mediated cardioprotective effects are largely offset by blockade of the exosome generation. A: A scheme of the experimental procedure for the treatment of mice with STZ and GW4869. B: Exosome concentration was measured in the serum of mice treated with GW4869 (n = 5). *P < 0.05 vs. WT; #P < 0.001 vs. DMSO-treated control groups. C: Representative echocardiographic images. LVIDd (D) and LVEF% (E) were calculated in various groups as indicated (n = 5 for buffer-treated groups and n = 7 for STZ-treated groups). *P < 0.05 vs. STZ/DMSO-treated WT. Hsp20-mediated attenuation of cardiomyocyte hypertrophy (F and G), cardiac apoptosis (H and I, arrows indicate TUNEL-positive nuclei), and Hsp20-mediated promotion of myocardial angiogenesis (J and K) were significantly limited by the GW4869 treatment (n = 5 hearts, with two sections from each heart). Scale bars: 100 μm. *P < 0.05 vs. STZ/DMSO-treated WT. Ctl, control; Mon, month.