Table 3.
Cardiovascular parameters in overnight-fasted healthy individuals following either placebo or DHEA administration during hypoglycemia (2.9 ± 0.1 mmol/L) on days 1 and 2
| Day 1 placebo |
Day 2 placebo |
Day 1 DHEA |
Day 2 DHEA |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Final | Δ | Baseline | Final | Δ | Baseline | Final | Δ | Baseline | Final | Δ | |
| Blood pressure (mmHg) | ||||||||||||
| Systolic | 115 ± 3 | 127 ± 4* | 12 ± 2† | 120 ± 2 | 124 ± 3 | 4 ± 2 | 118 ± 3 | 124 ± 4* | 7 ± 2‡ | 118 ± 3 | 132 ± 4* | 14 ± 3† |
| Diastolic | 68 ± 2 | 63 ± 2* | −5 ± 2 | 69 ± 2 | 63 ± 2* | −6 ± 2 | 66 ± 3 | 61 ± 2* | −6 ± 2 | 69 ± 3 | 65 ± 3* | −4 ± 2 |
| Mean arterial pressure (mmHg) | 84 ± 2 | 84 ± 2 | 1 ± 1 | 85 ± 2 | 83 ± 2 | −2 ± 1 | 84 ± 2 | 82 ± 2 | −2 ± 1‡ | 85 ± 2 | 87 ± 3 | 2 ± 1 |
| Heart rate (bpm) | 64 ± 3 | 78 ± 2* | 14 ± 3† | 67 ± 3 | 75 ± 3* | 8 ± 2 | 65 ± 3 | 74 ± 3* | 9 ± 2‡ | 67 ± 3 | 82 ± 2* | 15 ± 2 |
*P < 0.03–0.0001 compared with baseline;
†P < 0.04–0.009 compared with Δ in day 2 placebo;
‡P < 0.04–0.02 compared with Δ in day 1 DHEA.