Fig 1. Schematic representation of NDST1 gene.
The human NDST1 gene is located on chromosome 5 and encompasses 15 exons. The first exon and a part of the second are untranslated regions. NDST1 contains four alternative transcription starting sites indicated as PA, PB, PC, and PD. (A) The parametric clustering of CAGE sequences (green peaks) and DPI clusters (red and yellow arrows) indicates high tag expression level for PA region. (B) Transcription associated features such as CpG island, Pol II binding site and histone methylation/acetylation profile identifies PA region as the most usable promoter for NDST1 gene transcription. Data is filtered for K562 cell line. Screenshots for NDST1 promoter analysis were obtained from ZENBU genome browser (FANTOM5 Project) (http://fantom.gsc.riken.jp/zenbu/) and from UCSC Genome Database browser (http://genome.ucsc.edu/) using Human Feb. 2009 (GRCh37/hg19) Assembly.