Table 1. Characteristics of the included studies for the overall survival (OS) analysis.

First author	Year	Country	Cancer	Stage	Follow up(M)	Case(N)	Treatment	Technique	Location of staining	Cut off	Overall Survival		NOS
											Univariate analysis	Multivariate analysis
											HR (95% CI)	HR (95% CI)
Che JJ	2015	China	SCC	I, IIIa	70	103	pulmonectomy	IHC	membrane	>0%	2.08(1.34–3.21)	1.918(1.107–3.324)	8
Hroyasu N	2015	Japan	AC	I- III	38.1*	101	pulmonectomy	IHC	Cytoplasm	>median score		2.720 (1.23–6.52)	8
Terumasa S	2015	Japan	AC	Ia-IIIb	63*	239	pulmonectomy	IHC	Cytoplasm	scores≥2	2.41(1.3–4.46)		8
Xu MM	2014	China	NSCLC	I- III	60	150	pulmonectomy	IHC	Cytoplasm	>20%		0.580(0.389–0.867)	8
Kong FF	2014	China	NSCLC	I- IV	60	68	pulmonectomy	IHC	Cytoplasm	scores≥1	2.596(1.386–4.864)	1.287(0.642–2.580)	8
Zhang X	2014	China	NSCLC	I- IIIa	60	118	pulmonectomy	IHC	Cytoplasm	score≥3		1.664(1.031–2.686)	8
Guan XQ	2014	China	NSCLC	I-IV	60	500	pulmonectomy	IHC	Cytoplasm	score≥3	0.842(0.626–1.132)		7
Chao Z	2013	China	NSCLC	I- IV	39*	119	pulmonectomy	IHC	Cytoplasm	≥10%	2.21(1.21–4.039)	1.012(0.52–1.968)	8
Zhang H	2013	China	SCC	I- IIIa	51.5*	204	pulmonectomy	IHC	Cytoplasm	score≥4	1.435(1.086–1.896)	1.17(0.877–1.561)	8
Frank R (a)	2012	America	NSCLC	Ia- IV	24	57	chemotherapy	IHC	Cytoplasm	≥10%		0.65(0.31–1.38)	8
Frank R (b)	2012	America	NSCLC	Ia- IV	24	38	placebo	IHC	Cytoplasm	≥10%		2.32(1.09–4.94)	8
Zhou H	2012	China	NSCLC	I- III	41.5*	52	pulmonectomy	IHC	Cytoplasm	score≥3	3.45(1.66–7.11)		7
Shi YL	2011	China	NSCLC	I-IV	54	165	pulmonectomy	IHC	Cytoplasm	score≥4	2.18(1.43–3.24)		7
Ye T	2009	China	NSCLC	IIIa	36	75	pulmonectomy	IHC	Cytoplasm	score≥1	1.79(0.92–3.49)		7

NSCLC: non-small cell lung cancer, SCC: squamous cell carcinoma, AC: adenocarcinoma, IHC: immunohistochemistry, NOS: Newcastle-Ottawwwa-Scale.

*: median follow-up time.