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. 2016 Sep 22;11(9):e0163162. doi: 10.1371/journal.pone.0163162

Table 2. Characteristics of the included studies for the disease-free survival (DFS) analysis.

First author Year Country Cancer Stage Follow up(M) Case(N) Treatment Technique Location of staining Cut off Disease-free Survival NOS
Univariate analysis Multivariate analysis
HR (95% CI) HR (95% CI)
Hroyasu N 2015 Japan AC I- III 38.1* 101 pulmonectomy IHC Cytoplasm >median score 1.72(1.00–2.99) 8
Guan XQ 2014 China NSCLC I-IV 60 500 pulmonectomy IHC Cytoplasm score≥3 1.015(0.800–1.287) 8
Zhang H 2013 China SCC I- IIIa 51.5* 204 pulmonectomy IHC Cytoplasm score≥4 1.474(1.117–1.944) 1.164(0.873–1.552) 8
Yasuhiro C 2011 Japan NSCLC I- III 53.7* 183 pulmonectomy IHC NR ≥50% 1.326(0.634–2.770) 1.144(0.535–2.443) 8

NSCLC: non-small cell lung cancer, SCC: squamous cell carcinoma, AC: adenocarcinoma, IHC: immunohistochemistry, NOS: Newcastle-Ottawwwa-Scale.

*: median follow-up time.