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. 2016 Sep 22;11(9):e0163162. doi: 10.1371/journal.pone.0163162

Table 4. Analysis of relationships between vimentin and clinicopathological variables in NSCLC.

Clinicalpathological Variable No. of Studies model Cases (N) Pooled OR 95% CI P value Test for Heterogeneity
P value I2(95%CI) H(95%CI)
Age(≥ 60/<60) 24 Random effect 2810 0.927 0.789 1.088 0.353 0.799 0%(0%-45%) 1.0(1.0–1.3)
Gender(male/female) 25 Random effect 3105 1.122 0.944 1.332 0.192 0.473 0%(0%-44%) 1.0(1.0–1.3)
Diameter(>3.0cm/≤3.0 cm) 11 Random effect 1166 1.317 0.919 1.888 0.133 0.123 34%(0%-68%) 1.2(1.0–1.8)
Histology(SCC/AC) 20 Random effect 2259 0.821 0.684 0.986 0.034 0.644 0%(0%-48%) 1.0(1.0–1.4)
Smoking status(yes/no) 12 Random effect 2050 1.362 1.105 1.678 0.004 0.677 0%(0%-57%) 1.0(1.0–1.5)
Differentiation(poorly/moderate or well) 25 Random effect 2856 2.133 1.664 2.735 <0.001 0.048 34%(0%-60%) 1.2(1.0–1.6)
T stage(T2 or T3/T1) 6 Random effect 957 1.044 0.704 1.548 0.830 0.498 0%(0%-75%) 1.0(1.0–2.0)
TNM stages(III or IV/I or II) 20 Random effect 2661 3.069 1.894 4.974 <0.001 <0.001 80%(70%-87%) 2.3(1.8–2.8)
Vascular invasion(yes/no) 4 Random effect 722 3.492 1.063 11.472 0.039 0.001 83%(56%-93%) 2.4(1.5–3.9)
Lymph node metastasis(yes/no) 20 Random effect 2395 2.628 1.857 3.718 <0.001 <0.001 64%(41%-77%) 1.7(1.3–2.1)
Recurrence(yes/no) 3 Random effect 490 1.632 1.054 2.529 0.028 0.984 0%(0%-490%) 1.0(1.0–3.1)
Distant metastasis 2 Random effect 248 3.975 0.724 21.807 0.112 0.069 70% (-) (-)
Marginal invasion 2 Random effect 477 2.429 0.789 7.473 0.122 0.025 80% (-) (-)
Pleural invasion 2 Random effect 290 2.344 1.395 3.393 0.001 0.794 0% (-) (-)

SCC: squamous cell carcinoma, AC: Adenocarcinoma.