Table 2. Cox Regression Analyses for Cancer-specific Survival in Laryngeal Squamous Cell Carcinoma.
| Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95%CI) | P Value | HR(95% CI) | P value | |
| Age | ||||
| <60 | 1 (reference) | 0.001 | 1 (reference) | 0.002 |
| ≥60 | 1.48 (1.18–1.86) | 1.43 (1.13–1.80) | ||
| Gender | ||||
| Female | 1 (reference) | 0.051 | ND | ND |
| Male | 0.38 (0.14–1.01) | |||
| Smoking | ||||
| No | 1 (reference) | 0.139 | ND | ND |
| Yes | 1.35 (0.91–2.02) | |||
| Drinking | ||||
| No | 1 (reference) | 0.001 | 1 (reference) | 0.001 |
| Yes | 1.47 (1.17–1.84) | 1.50 (1.19–1.89) | ||
| Neck dissection | ||||
| No | 1 (reference) | < 0.001 | NS | |
| Yes | 2.01 (1.59–2.55) | |||
| Tumor subsite | ||||
| Supraglottic | 1 (reference) | < 0.001 | NS | |
| Glottic | 1.85 (1.47–2.33) | |||
| T stage | ||||
| T1 | 1 (reference) | < 0.001 | 1 (reference) | <0.001 |
| T2 | 1.37 (0.96–1.94) | 1.22 (0.85–1.73) | ||
| T3 | 2.24 (1.59–3.15) | 1.69 (1.18–2.41) | ||
| T4 | 3.28 (2.31–4.66) | 2.10 (1.43–3.09) | ||
| N stage | ||||
| N0 | 1 (reference) | < 0.001 | 1 (reference) | <0.001 |
| N1 | 2.69 (1.95–3.70) | 1.81 (1.28–2.56) | ||
| N2 | 2.51 (1.78–3.53) | 1.81 (1.25–2.62) | ||
| N3 | 18.68 (7.54–46.30) | 11.71 (4.61–29.79) | ||
| Histological Differentiation | ||||
| high | 1 (reference) | < 0.001 | 1 (reference) | 0.049 |
| moderate | 1.51 (1.17–1.95) | 1.24 (0.95–1.61) | ||
| poor | 2.04 (1.50–2.79) | 1.50 (1.08–2.08) | ||
| COR-BMI | ||||
| 0 | 1 (reference) | < 0.001 | 1 (reference) | 0.001 |
| 1 | 1.92 (1.08–3.43) | 1.76 (0.98–3.15) | ||
| 2 | 3.25 (1.72–6.16) | 2.91 (1.53–5.54) | ||
Abbreviations: COR-BMI = Combination of red blood cell distribution width and body mass index; CI = confidence interval; HR = hazard ratio; N = node; T = tumor; ND = not done; NS = not significant.