Table 2. Duration of therapy and dose of individual antipsychotic agents by case patients with acute coronary syndrome and controls.
| Cases (n = 147) | Controls (n = 2940) | Multivariate Adjusted Model | |||||
|---|---|---|---|---|---|---|---|
| Characteristic | n (use) | Mean (SD) of all cases | N (use) | Mean (SD) of all controls | Adjustedrisk ratioa | 95% CI | P-value |
| Current users (duration of use within 30 days before the index date, days) | |||||||
| Chlorpromazine | 15 | 2.4 (7.6) | 109 | 0.7 (4.0) | 1.05** | 1.02–1.09 | 0.002 |
| Haloperidol | 40 | 3.5 (7.8) | 404 | 2.1 (6.7) | 1.01 | 0.98–1.04 | 0.388 |
| Flupentixol | 11 | 0.6 (4.0) | 197 | 0.7 (4.2) | 1.03 | 0.98–1.08 | 0.298 |
| Sulpiride | 35 | 3.8 (8.2) | 411 | 2.6 (7.6) | 1.02 | 0.99–1.05 | 0.135 |
| Clozapine | 5 | 0.5 (3.1) | 273 | 1.5 (5.9) | 0.96 | 0.91–1.02 | 0.200 |
| Olanzapine | 4 | 0.3 (1.8) | 207 | 1.4 (5.7) | 0.91 | 0.80–1.04 | 0.165 |
| Quetiapine | 17 | 1.8 (5.4) | 181 | 1.2 (5.2) | 1.02 | 0.99–1.06 | 0.212 |
| Zotepine | 7 | 0.9 (4.3) | 123 | 0.7 (3.9) | 1.02 | 0.98–1.07 | 0.325 |
| Risperidone | 25 | 2.1 (6.2) | 576 | 3.2 (8.1) | 0.97 | 0.93–1.01 | 0.127 |
| Amisulpride | 9 | 1.1 (5.1) | 109 | 0.7 (4.0) | 0.99 | 0.94–1.04 | 0.786 |
| Aripiprazole | 6 | 0.8 (4.3) | 45 | 0.3 (2.7) | 1.06* | 1.01–1.11 | 0.013 |
| Current users (cumulative defined daily dose within 30 days before index date, DDD) | |||||||
| Chlorpromazine | 15 | 0.7 (3.0) | 109 | 0.3 (2.9) | 1.04 | 1.00–1.08 | 0.079 |
| Haloperidol | 40 | 2.6 (11.4) | 404 | 2.4 (11.0) | 1.00 | 0.99–1.02 | 0.667 |
| Flupentixol | 11 | 0.6 (5.0) | 197 | 0.9 (6.5) | 1.01 | 0.98–1.04 | 0.565 |
| Sulpiride | 35 | 2.1 (8.2) | 411 | 1.7 (6.6) | 1.00 | 0.97–1.04 | 0.858 |
| Clozapine | 5 | 0.2 (1.4) | 273 | 0.9 (4.5) | 0.93 | 0.82–1.05 | 0.253 |
| Olanzapine | 4 | 0.2 (1.9) | 207 | 1.5 (7.9) | 0.91 | 0.80–1.04 | 0.182 |
| Quetiapine | 17 | 0.9 (5.1) | 181 | 1.0 (6.5) | 1.01 | 0.98–1.04 | 0.563 |
| Zotepine | 7 | 0.4 (3.0) | 123 | 0.4 (2.8) | 1.03 | 0.97–1.10 | 0.349 |
| Risperidone | 25 | 0.8 (3.9) | 576 | 1.8 (6.1) | 0.91 | 0.82–1.01 | 0.063 |
| Amisulpride | 9 | 0.7 (3.8) | 109 | 0.9 (6.5) | 0.99 | 0.95–1.04 | 0.674 |
| Aripiprazole | 6 | 0.5 (3.1) | 45 | 0.2 (2.1) | 1.07* | 1.01–1.13 | 0.025 |
*P<0.05.
**P<0.01.
aAdjusted for Charlson comorbidity index at the first admission and the following variables within 180 days before the index date, including the number of psychiatric hospital admissions, substance use disorders, physical illnesses, and concomitant medications (listed in Table 1).