Fig 3. Acquired multidrug-resistance in Nigerian S. Typhi isolates.
Maximum likelihood tree of 128 Nigerian S. Typhi isolates from 2,541 SNPs is shown on the left. On the right is a heatmap which shows, for each isolate, its multidrug-resistant (MDR) status (purple), the presence of gyrA mutations (dark green S83Y; light green S83F), resistance genes cat, blaTEM, dfrA, sul1/2, strAB, tetB/AR, qnr (red) and plasmids, including IncHI1 (dark blue), Kpn3 (light blue), IncY (orange), IncQ1 (light pink), IncFIIs (yellow) and Col(RNAI) (magenta). Different colored bars within the plasmid column show isolates that harbor multiple plasmids with each bar representing a plasmid type. The absence of a genotype or plasmid was displayed in grey. Branch lengths are indicative of the estimated substitution rate per variable site.