Figure 11. Model for CD301b⁺ DC-mediated suppression of humoral immunity.

(a) Summary of the results shown in this study. (b) Model for Tfh and GCB cell suppression by CD301b⁺ DCs. CD301b⁺ DCs express high levels of PD-L1 to inhibit the expansion of Tfh. The impaired Tfh expansion in turn leads to suboptimal GC B cell activation and reduced antibody responses. In the absence of CD301b⁺ DCs, CD301b^-LN-resident DCs present soluble antigens to CD4⁺ T cells to induce Tfh differentiation. This CD301b^-LN-resident DC subset is susceptible to depletion in CD11c-DTR mice.

DOI: http://dx.doi.org/10.7554/eLife.17979.018