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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Arch Toxicol. 2016 Mar 22;91(2):761–773. doi: 10.1007/s00204-016-1692-0

Figure 1. MT protected against APAP hepatotoxicity.

Figure 1

Mice were treated with 300 mg/kg APAP, and 10 or 20 mg/kg MT or saline (10 ml/kg) was given 1.5 h later. Blood and liver tissue were harvested at 3 or 6 h post-APAP. (A) Plasma alanine aminotransferase (ALT) activity. (B) Area of necrosis at 6 h (%). (C) H&E stained liver sections. Bars represent means ± SEM for n = 4 – 7 mice. *p<0.05 vs. 0h. #p<0.05 vs. APAP. $p<0.05 vs. APAP+10 mg/kg MT.