| Treatment | DEN/CCl4 | DEN/TCPOBOP | ||
|---|---|---|---|---|
| Cre Driver | AAV-TBG-Cre | Foxl1-Cre | AAV-TBG-Cre | Foxl1-Cre |
| Labeled cells | Hepatocytes | HPCs | Hepatocytes | HPCs |
| Number of mice | 9 | 9 | 11 | 9 |
| Number of HCAs analyzed | 27 | 6 | 7 | 17 |
| Number of YFP+ HCAs | 26 | 0 | 7 | 0 |
| Number of HCCs analyzed | 3 | 0 | 1 | 8 |
| Number of YFP+ HCCs | 3 | 0 | 1 | 0 |
| Number of HCCs with Sox9+ tumor-associated duct structures | 3 | 0 | 0 | 8 |
| Number of HCCs with Sox9+ parenchymal cells | 3 | 0 | 1 | 6 |
| Number of OPN+ HCCs | 3 | 0 | 1 | 8 |
| Number of Yap1+ HCCs | 3 | 0 | 1 | 8 |
| Number of HCCs with EpCAM+ tumor-associated duct structures | 3 | 0 | 0 | 7 |
| Number of HCCs with EpCAM+ parenchymal cells | 0 | 0 | 1 | 4 |
| Number of CK19+ HCC nodules | 0 | 0 | 0 | 7 |
| Number of HCCs with nuclear β-catenin-positive parenchymal cells | 0 | 0 | 1 | 7 |
| Number of Afp+ HCC nodules | 3 | 0 | 1 | 8 |
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