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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Hepatology. 2016 Jun 15;64(4):1189–1201. doi: 10.1002/hep.28641

Figure 1.

Figure 1

Figure 1

Liver histology in ARE-Del−/− mice. 1A. Representative H&E staining of male and female ARE-Del−/− mice. Arrow bars point to the inflammatory foci region. 1B. Representative H&E staining of portal inflammation (arrow bar: bile duct showing mild damage), lobular inflammation (arrow bar: focal necrosis), biliary duct damage (arrow bar: bile duct showing moderate damage) and granuloma formation (arrow bar: epithelioid granuloma in portal tract) in female ARE-Del−/− mice. 1C. Statistical analysis of liver histology of male and female ARE-Del−/− mice was performed by the nonparametric Mann Whitney test using GraphPad Prism 6.0 (mean ± SEM; n=16 from three independent experiments). The two-tailed p-value < 0.05 was taken as significance (* P < 0.05, ** P < 0.01, *** P < 0.001, n.s., not significant). 1D. Representative Sirius Red staining of liver fibrosis in female ARE-Del−/− mice at age 20 wks. Scale bar: 200 μm (A left and D top); 50 μm (A right, B and D bottom).