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. Author manuscript; available in PMC: 2016 Sep 22.
Published in final edited form as: Rev Physiol Biochem Pharmacol. 2016;171:39–62. doi: 10.1007/112_2016_2

Fig. 3.

Fig. 3

Oxidative stress can increase diastolic SR Ca2+ leak by inducing intersubunit cross-linking within the ryanodine receptor complex. The RyR2 tetramer is shown as viewed from the cytoplasmic face