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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Hepatology. 2016 Jul 22;64(4):1057–1071. doi: 10.1002/hep.28680

Figure 4. Inhibition of SYK activation suppressed alcohol-induced inflammasome activation and IL-1β production.

Figure 4

C57BL/6 mice were fed using the moderate ASH (A–C) or chronic (D) alcohol feeding model with SYK inhibitor (SYK Inh.) or vehicle treatment (+ Veh.). Total RNA was extracted from mouse livers and assessed by RT-qPCR for IL-1β mRNA (A). Liver protein was assessed by western blot for cleaved caspase-1 with β-actin as a protein loading control (B). Serum samples from mice were analyzed by ELISA for IL-1β (C&D). A p-value <0.05 was considered statistically significant by ANOVA for 6–8 mice per experimental group (*, p<0.05 compared to baseline; #, p<0.05 compared to EtOH + vehicle group).