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. Author manuscript; available in PMC: 2017 Sep 21.
Published in final edited form as: Neuron. 2016 Sep 8;91(6):1253–1259. doi: 10.1016/j.neuron.2016.08.013

Table 1.

Genotype × strain interactions.

Phenotype Genetic background × null allele (ANOVA p-value) Phenotypic variance explained
Cacna1c study
Percent time in the light box 0.20 4.3%
Exploratory activity 0.01* 3.4%
Duration in center 9.9e-08*** 7.4%
Methamphetamine sensitivity 9.5e-3** 4.1%
Immobility 7.4e-3** 4.4%
Acoustic startle response 0.08 1.6%
Tcf7l2 study
Body weight 0.42 0.5%
Exploratory activity 6.8e-06*** 7.0%
Duration in center 6.8e-07*** 5.8%
Contextual fear learning 0.23 3.5%
Cued fear learning 0.08 4.2%
Acoustic startle response 8.9e-08*** 4.2%
Prepulse inhibition 8.7e-04*** 8.1%
Fasted blood glucose levels 0.24 3.4%
Baseline blood glucose levels 0.05 4.2%
*

p<0.05,

**

p<0.01,

***

p<0.001.

Opposite effects of the null allele in different F1 backgrounds.

See Table S3 for the analysis of variance (ANOVA) of each phenotype.

See Figure S1 for a comparison of main and interactive effects.