Scheme 2.
Synthesis of 11a-11h with modifications at the 2-position of the quinazoline ring
Reagents and conditions: (a) 2,3-dihydro-1H-inden-2-amine, K2CO3, DMF; (b) RB(OH)2, Pd(PPh3)4, K2CO3, 1,4-dioxane, H2O
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