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. Author manuscript; available in PMC: 2017 Sep 22.
Published in final edited form as: J Med Chem. 2016 Sep 6;59(18):8508–8520. doi: 10.1021/acs.jmedchem.6b00930

Table 1.

Structure and inhibitory activity of 2-(pyridin-3-yl)quinazoline derivatives with substituted cyclohexyl and related ringsa

graphic file with name nihms812481t1.jpg
Comp. R IC50 (µM) Comp. R IC50 (µM)
4 graphic file with name nihms812481t2.jpg 0.177 ± 0.012 6f graphic file with name nihms812481t3.jpg 0.234 ± 0.017
6a graphic file with name nihms812481t4.jpg 0.056 ± 0.005 6g graphic file with name nihms812481t5.jpg Inactive
6b graphic file with name nihms812481t6.jpg 0.126 ± 0.007 6h graphic file with name nihms812481t7.jpg 0.891 ± 0.023
6c graphic file with name nihms812481t8.jpg 0.020 ± 0.002 6i graphic file with name nihms812481t9.jpg Inactive
6d graphic file with name nihms812481t10.jpg 0.251 ± 0.018 6j graphic file with name nihms812481t11.jpg 33.21 ± 9.71
6e graphic file with name nihms812481t12.jpg 0.431 ± 0.042 6k graphic file with name nihms812481t13.jpg 36.07 ± 8.72
a

Experiments were performed in triplicate, and the mean ± SD is shown.