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. Author manuscript; available in PMC: 2017 Sep 22.
Published in final edited form as: J Med Chem. 2016 Sep 6;59(18):8508–8520. doi: 10.1021/acs.jmedchem.6b00930

Table 2.

Structure and inhibitory activity of 2-(pyridin-3-yl)quinazoline derivatives with saturated alkyl ringsa

graphic file with name nihms812481t14.jpg
Comp. R IC50 (µM) Comp. R IC50 (µM)
7a graphic file with name nihms812481t15.jpg 0.027 ± 0.002 7f graphic file with name nihms812481t16.jpg 0.926 ± 0.08
7b graphic file with name nihms812481t17.jpg 0.042 ± 0.003 7g graphic file with name nihms812481t18.jpg 0.282 ± 0.043
7c graphic file with name nihms812481t19.jpg 0.72 ± 0.05 7h graphic file with name nihms812481t20.jpg 0.405 ± 0.040
7d graphic file with name nihms812481t21.jpg 2.84 ± 0.34 7i graphic file with name nihms812481t22.jpg 0.857 ± 0.033
7e graphic file with name nihms812481t23.jpg 28.07 ± 3.21
a

Experiments were performed in triplicate, and the mean ± SD is shown.