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. Author manuscript; available in PMC: 2017 Sep 22.
Published in final edited form as: J Med Chem. 2016 Sep 6;59(18):8508–8520. doi: 10.1021/acs.jmedchem.6b00930

Table 4.

Structure and inhibitory activity of 2-(pyridin-3-yl)quinazoline derivatives with fused ringsa

graphic file with name nihms812481t32.jpg
Comp. R IC50 (nM) Comp. R IC50 (nM)
9a graphic file with name nihms812481t33.jpg 8.7 ± 1.1 9d graphic file with name nihms812481t34.jpg 872 ± 71
9b graphic file with name nihms812481t35.jpg 9.9 ± 1.3 9e graphic file with name nihms812481t36.jpg 821 ± 73
9c graphic file with name nihms812481t37.jpg 8.3 ± 1.0 9f graphic file with name nihms812481t38.jpg 35 ± 3
a

Experiments were performed in triplicate, and the mean ± SD is shown.