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. 2016 Sep 22;1(15):e87536. doi: 10.1172/jci.insight.87536

Figure 3. Chronic bronchitis exacerbations in cigarette smoke-exposed ferrets.

Figure 3

(A) Kaplan-Meier survival curve of ferrets exposed to cigarette smoke or room air for 6 months. (B) Body weight changes observed in cigarette smoke–exposed ferrets compared with air controls over 6 months of exposure. (C) Image (original magnification, ×2) capturing evidence of mucus obstruction in a large airway shown in a smoke-exposed ferret that suffered from spontaneous lung infection with Staphylococcus xylosus and Staphylococcus schleiferi. (D and E) Histopathologic examination confirmed mucus accumulation in the trachea by PAS staining (D, yellow arrow; scale bar: 135 μm) and inflammatory foci (E; scale bar: 135 μm) in lung highlighted by H&E staining. n = 8/group. **P < 0.01, ****P < 0.0001.