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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Glia. 2016 Jun 3;64(8):1363–1380. doi: 10.1002/glia.23009

Fig. 7. ApoE promotes oligodendroglial differentiation via LRP1.

Fig. 7

The results of the differentiation assay: A. illustrating that lipid-free ApoE4 addition to the differentiation medium increases the amount of O4-positive oligodendrocytes generated from LRP1+/+ (N = 4). This suggests that LRP1-dependent ApoE uptake promotes the differentiation of NSPCs towards oligodendrocytes. B. Oligodendroglial differentiation of LRP1−/− NSPCs is not altered upon ApoE4 treatment. Data are expressed as mean ± SE (* indicates P < 0.05, ** — P < 0.01).