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. 2016 Aug 11;291(39):20427–20439. doi: 10.1074/jbc.M116.744656

TABLE 2.

Proposed contributions of LCAT and ACAT1 to cholesterol esterification in the retina

+, minor contribution; +++, significant contribution.

Cholesterol-esterifying enzyme Hypocholesterolemic retina
Normocholesterolemic retina
Hypercholesterolemic retina
Mice Mice Humans Mice Humans
LCAT +++ +++ +++ +++ +++
ACAT1 + + + +++ +