FIGURE 2.

CYP17A1, CYP21A2, CYP19A1 (aromatase), and CYP3a11 activities supported by WT and A287P POR proteins. A, percentage of progesterone converted to 17-OH-progesterone by CYP17A1 and 21-OH progesterone by CYP21A2. B, aromatase activity as measured by conversion of androstenedione to estrone. C, conversion of BFC to HFC by xenobiotic-metabolizing CYPs. Black bars are WT POR and gray bars are A287P. Assays were repeated at least three times and were performed as described under “Experimental Procedures.”