FIGURE 6.
Treatment of HP diet-induced phenotype by OHCbl. A, cobalamin levels in plasma of untreated mice and OHCbl-treated mice (*, p < 0.0001). B, time course of body weight. The black arrow indicates start of HP diet on day 60. Differences of body weight on day 64 were significant between Mutko/ki and the other two genotypes (Mutki/ki and wt), which did not differ significantly from each other. C–E, C3 (normalized to C2) (C), MMA levels in dried blood (D), and whole blood ammonia levels (E) were measured on the day the diet was started (day 60) and on days 62 and 64 following diet commencement. F, weights of brain whole organs in sacrificed animals at the end of the study. In B–E duration of HP diet was from days 60 to 64 and OHCbl treatment from days 53 to 64 as indicated by capped horizontal lines. Points and bars represent mean values; error bars in all panels depict S.E.