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. 2016 Jul 22;291(39):20692–20706. doi: 10.1074/jbc.M116.732719

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Proposed working model accounting for the TIP150-CTN interaction in directional cell migration. TIP150 functions as a microtubule plus end stabilizer that interacts with CTN to promote microtubule-actin cortex interaction. EGF stimulation promotes phosphorylation of CTN, which accelerates a dynamic TIP150-CTN interaction at the leading edges of migrating cells for directional movement. Thus, the TIP150-CTN complex serves as a link to orchestrate directional cell migration via coupling dynamic microtubule plus ends with the cell cortex.