Figure 1.

Genetic screen identifies regulators of ferroptosis. (A) RNAi screening strategy to identify novel players of ferroptosis. (B) Plot of z-score (frequency of a specific shRNA in total sequencing reads calculated from ferroptosis-treated cells over the frequency calculated from control cells) of the RNAi screen results shows the enrichment of individual shRNAs. (C) Multiple known ferroptosis regulators were enriched in our RNAi screening. (D) Multiple autophagy-related genes were enriched in our RNAi screening.