Table 1.

Examples of dichotomized responder end points used in clinical trials of RA

Continuous end point	Responder end point	Absolute or relative to baseline	Thresholds typically used
ACR-N	ACR20, ACR50, ACR70	Relative to baseline	20%, 50%, 70%
DAS28	Remission, low disease activity, moderate disease activity	Absolute disease activity	2.6, 3.2, 5.1
SDAI			3.3, 11, 26
CDAI			2.8, 10, 22
HAQ-DI	HAQ-DI response, according to minimally important difference	Relative to baseline	0.22, 0.25, 0.3 (various thresholds used)

SDAI: simple disease activity index; CDAI: clinical disease activity index; HAQ-DI: Health assessment questionnaire disability index.