Table 2. Cytotoxicity of zephycandidine A (1) (IC50 in μM) against five cancer cell lines and a non-cancerous human Beas-2B cell linea.
Compound | HL-60 | A549 | MCF-7 | SW480 | SMMC-7721 | BEAS-2B | Highest index of selectivity |
---|---|---|---|---|---|---|---|
1 | 1.98 | 6.49 | 3.44 | 6.27 | 7.03 | 20.08 | 10 |
cis-platin | 3.12 | 8.95 | 18.48 | 11.37 | 9.82 | 13.30 | 4.3 |
aThe “Highest index of selectivity” is the ratio of the IC50 value for the Beas-2B cell line over the lowest cancer cell IC50 value. cis-Platin was used as a positive control.