Figure 5. Two possible schemes of control for the interneuronal circuit.

We built a simplified circuit model containing VIP, SOM and pyramidal neurons. (a–c) Control signals target only VIP neurons. (a) In this scheme, for each pathway, control inputs target a random subset of VIP neurons. And the connection probability from VIP to SOM neurons is P_VIP→SOM. (b,c) Good gating selectivity is only achieved when a small subset of VIP neurons is targeted by control inputs (b), and when the VIP–SOM connections are sparse (c). (d–f) Control signals target both VIP and SOM neurons. (d) In this scheme, we assume that for each pathway control inputs target a random subset of VIP and SOM neurons. (e) Gating selectivity depends on the proportion of SOM (blue) but not VIP (green) neurons targeted by control input. (f) Gating selectivity does not depend on P_VIP→SOM. Curves and shaded regions are as in Fig. 4.