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. 2016 Sep 20;7:12815. doi: 10.1038/ncomms12815

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Copyright © 2016, The Author(s)

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(a) PV neurons project to the somatic areas of pyramidal neurons, and are inhibited by SOM neurons and themselves. Suppression of SOM neurons causes disinhibition of PV neurons, therefore an increase in somatic inhibition onto pyramidal neurons. (b) A moderate increase in somatic inhibition always improves gating selectivity. We included PV neurons and their corresponding connections in the model of Fig. 5d. Gating selectivity increases as a function of the SOM-to-PV connection weights (w_SOM→PV) in a wide range (see Supplementary Note 1 for a proof). However, when gating selectivity is low without PV neurons (light curve), the peak of this increase is lower and the slope is sharper. Gating selectivity starts to decrease when the SOM-to-PV connection, therefore the somatic inhibition, is too strong that the responses of many pyramidal neurons are completely suppressed.