. 2016 Jul 9;27(9):2014–2023. doi: 10.1021/acs.bioconjchem.6b00306

Table 1. Biodistribution (%ID/g) of the Six Radiolabeled N-Terminus Derivatized NOTA-pHLIP Derivatives in 4T1 Allografted Female BALB/c Mice at 4 h p.i.

tissue	⁶⁴Cu-NOTA-WT (n = 4)	⁶⁴Cu-NOTA-Var3 (n = 5)	⁶⁴Cu-NOTA-Var7 (n = 4)	¹⁸F-AlF-NOTA-WT (n = 5)	¹⁸F-AlF-NOTA-Var3 (n = 4)	¹⁸F-AlF-NOTA-Var7 (n = 5)
blood	1.192 ± 0.263	1.371 ± 0.244	0.833 ± 0.068	1.978 ± 0.192	2.201 ± 0.374	2.292 ± 0.277
heart	0.50 ± 0.04	0.49 ± 0.05	0.35 ± 0.04	0.66 ± 0.12	0.78 ± 0.08	0.78 ± 0.06
lungs	1.414 ± 0.083	1.420 ± 0.117	0.996 ± 0.066	2.049 ± 0.211	2.217 ± 0.380	2.325 ± 0.212
liver	0.904 ± 0.097	1.034 ± 0.150	0.739 ± 0.041	0.973 ± 0.213	0.923 ± 0.153	1.089 ± 0.066
spleen	0.318 ± 0.023	0.340 ± 0.032	0.279 ± 0.016	0.434 ± 0.058	0.469 ± 0.093	0.485 ± 0.029
pancreas	0.261 ± 0.066	0.279 ± 0.041	0.198 ± 0.043	0.324 ± 0.059	0.332 ± 0.020	0.373 ± 0.051
stomach	0.282 ± 0.080	0.194 ± 0.050	0.300 ± 0.076	0.518 ± 0.152	0.482 ± 0.223	0.593 ± 0.153
s. intestine	0.391 ± 0.082	0.320 ± 0.042	0.307 ± 0.077	0.820 ± 0.245	0.927 ± 0.152	0.776 ± 0.196
l. intestine	9.96 ± 3.42	7.45 ± 2.73	7.78 ± 0.61	24.06 ± 2.85	22.05 ± 2.46	22.08 ± 6.02
kidneys	6.232 ± 0.613	7.165 ± 1.126	6.790 ± 0.461	8.550 ± 1.138	8.237 ± 1.106	7.759 ± 0.658
muscle	0.166 ± 0.008	0.171 ± 0.017	0.118 ± 0.025	0.283 ± 0.041	0.282 ± 0.055	0.325 ± 0.073
bone	0.274 ± 0.051	0.339 ± 0.018	0.229 ± 0.093	0.671 ± 0.305	0.540 ± 0.119	0.571 ± 0.202
skin	0.715 ± 0.109	0.775 ± 0.102	0.563 ± 0.145	1.032 ± 0.133	1.126 ± 0.115	1.377 ± 0.148
brain	0.054 ± 0.002	0.063 ± 0.011	0.042 ± 0.004	0.100 ± 0.015	0.107 ± 0.023	0.118 ± 0.011
tumor	0.679 ± 0.025	0.649 ± 0.091	0.546 ± 0.075	1.005 ± 0.232	0.923 ± 0.119	1.105 ± 0.125