. 2016 Jul 9;27(9):2014–2023. doi: 10.1021/acs.bioconjchem.6b00306

Table 2. Biodistribution (%ID/g) of the Six Radiolabeled Cysteine Derivatized NO2A-cyspHLIP Derivatives in 4T1 Allografted Female BALB/c Mice at 4 h p.i.

tissue	⁶⁴Cu-NO2A-cysWT (n = 4)	⁶⁴Cu-NO2A-cysVar3 (n = 5)	⁶⁴Cu-NO2A-cysVar7 (n = 4)	¹⁸F-AlF-NO2A-cysWT (n = 4)	¹⁸F-AlF-NO2A-cysVar3 (n = 10)	¹⁸F-AlF-NO2A-cysVar7 (n = 4)
blood	17.6 ± 0.86	15.4 ± 1.76	2.31 ± 0.18	15.9 ± 0.63	20.8 ± 1.88	1.64 ± 0.18
heart	5.52 ± 0.15	5.12 ± 0.63	2.68 ± 0.33	4.78 ± 0.53	6.29 ± 1.03	0.89 ± 0.12
lungs	12.3 ± 1.55	14.7 ± 0.93	4.21 ± 0.23	8.73 ± 0.84	11.8 ± 3.79	1.66 ± 0.07
liver	21.9 ± 0.64	10.4 ± 0.63	15.6 ± 1.58	12.6 ± 11.4	9.06 ± 1.24	2.90 ± 0.18
spleen	7.07 ± 0.44	3.45 ± 0.35	3.31 ± 0.24	5.31 ± 0.34	3.73 ± 0.66	1.19 ± 0.10
pancreas	3.00 ± 0.08	2.31 ± 0.25	1.84 ± 0.10	2.10 ± 0.43	2.44 ± 0.20	0.49 ± 0.03
stomach	1.82 ± 0.13	1.27 ± 0.35	3.33 ± 0.31	1.31 ± 0.96	1.29 ± 0.62	0.68 ± 0.10
s. intestine	4.56 ± 0.26	2.68 ± 0.24	6.37 ± 0.11	2.85 ± 0.31	2.06 ± 0.28	0.91 ± 0.03
l. intestine	4.09 ± 0.34	2.99 ± 0.20	8.19 ± 0.85	1.47 ± 0.14	2.07 ± 0.63	0.91 ± 0.12
kidneys	40.6 ± 4.04	24.0 ± 2.78	95.5 ± 11.9	59.1 ± 3.63	34.3 ± 6.91	246 ± 25.6
muscle	1.15 ± 0.08	1.10 ± 0.15	0.64 ± 0.07	1.23 ± 0.17	1.55 ± 0.27	0.35 ± 0.06
bone	3.04 ± 0.11	1.10 ± 0.14	1.57 ± 0.18	1.94 ± 0.45	1.66 ± 0.61	0.60 ± 0.12
skin	3.23 ± 0.12	3.43 ± 0.34	2.59 ± 0.05	2.85 ± 0.22	2.92 ± 0.71	1.59 ± 0.10
brain	0.62 ± 0.06	0.35 ± 0.07	0.25 ± 0.02	0.34 ± 0.06	0.52 ± 0.14	0.05 ± 0.01
tumor	11.7 ± 1.71	8.21 ± 0.86	9.07 ± 1.81	8.16 ± 0.53	10.6 ± 2.26	8.61 ± 1.21