Figure 2.

Water flux through the transmembrane region. The number of water molecules traversing the TM domain as a function of time (EC $\to$ IC, solid lines; IC $\to$ EC, dashed lines). Water fluxes (j) through the receptor, calculated using the slope from linear fits to the data over the interval 400 < t < 1200 ns, are j ≈ 30 (antagonist), 20 (apo), and 10 μs⁻¹ (agonist). To see this figure in color, go online.