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. 2016 Sep 23;18:212. doi: 10.1186/s13075-016-1106-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Trimmed analysis of differences from comparator in mTSS at month 6 and month 12 in ORAL Scan and ORAL Start. 0 % trimming represents the primary analysis. ^aPercentage of data excluded; LS mean differences from PBO (ORAL Scan) or MTX (ORAL Start) with 95 % CIs of each tofacitinib group vs comparator are presented; a CI that does not contain 0 indicates that the difference is statistically significant (p < 0.05). BID twice daily, CI confidence interval, LS least squares, mTSS van der Heijde modified total Sharp score, MTX methotrexate, N number of patients eligible for analysis, PBO placebo