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. 2016 Sep 22;47:96. doi: 10.1186/s13567-016-0380-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Brain PrP ^res from Q ₂₂₂ -Tg501 and K ₂₂₂ -Tg516 mice inoculated with an atypical scrapie isolate. Immunoblots of brain PrP^res detected with 12B2 mAb of atypical scrapie isolates before and after transmission in either Q₂₂₂-Tg501 or K₂₂₂-Tg516 mice. Sheep classical scrapie and uninfected sheep brain were included on the right. Similar amounts of 10% brain homogenate were loaded in each lane for comparison. Both Q₂₂₂-Tg501 and K₂₂₂-Tg516 mice showed a similar PrP^res ladder pattern characteristic of atypical scrapie. Molecular masses (kDa) are shown on the right.