Fig. 1.

Diastolic dysfunction appears in the early phase of pressure overload. After 30 min of transverse aortic constriction (TAC) in C57 mice, invasive hemodynamics were evaluated. a Left ventricular systolic pressure (LVSP). b Left ventricular end-diastolic pressure (LVEDP). c Heart rate. d Maximum rate of change in left ventricular pressure (dp/dt max). e Minimum rate of change in left ventricular pressure (dp/dt min). f Exponential time constant of relaxation (τ). g dp/dt max corrected with LVSP. h dp/dt min corrected with LVSP. *P < 0.05 versus the sham group, n = 6 and 9 in the sham and TAC groups, respectively